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This is an illness that we quite
commonly see as Rheumatologists.
It is often seen in articles in the lay press and several of my new patients have come
into my rooms having read about it - and asking if this is the problem they have.
It is characterized by
stiffness and aching in the musculoskeletal system, especially at the shoulder girdle and
the pelvic and limb girdles.
The symptoms are worse in the morning and patients may complain of difficulty getting out
of bed and difficulty lifting their arms above their heads.
There may be a fever and loss of weight as well.
The condition usually arises over
the age of 50-60 years and is twice as common in females as men. The annual incidence is
approximately 50 / 100000 people per year and the prevalence is approximately 33 / 1000 0f
the population above age 65.
The cause is unknown,
but there seems to be a genetic background and an immune mechanism.
The condition has some relationship to Giant cell arteritis - also known as temporal
arteritis.
Physical examination often reveals very little -
The most common findings are soft tissue in character...
For example:
Rotator cuff /subachromial bursitis / shoulder tendonitis Trochanteric Bursitis.
Vague tenderness of the proximal muscles of the thighs and upper limbs.
An arthritis may some times be seen - in approximately 50 % of cases - usually a mild
synovitis However an erosive arthritis has been demonstrated to occur in some case reports
and variably up to 4% of cases.
Unlike Temporal
arteritis there is no definite confirmed association with underlying cancers.
Blood tests
The ESR and CRP are classically
elevated - although a small percentage of patients may have a normal test.
There may be a mild anemia.
The rheumatoid factor is not elevated - but remember - the condition is seen in the
elderly and a false positive elevation of the Rheumatoid factor may be seen anyway.
Treatment.
Classically the condition is very responsive to steroid therapy, given as oral tablets -
i.e. prednisone.
My method is to start at a lower dose than classically described ( 20mg)- I
use 10mg and only go up to 20 mg if there is no response.
I usually find 20 mg is enough.
Then starts the difficult part...the weaning of the dose.
Most patients go down to 7.5mg at 1 months and then I try to go down to
5 mg at 3 months ... then down to ...
2.5mg at 5 months and then ...
2.5mg alternate day at 8 months.. then ...
2.5mg every third day at 10 months and hopefully ....
Stop at 12 months.
Some patients require a small maintenance dose of 2.5mg alt day or every third day
ongoing.
However I am not personally anxious about this as the side effect profile at this dose is
very small.
A nocturnal anti-inflammatory may be useful in some patients.
Physical therapy may be useful.
Diet - I suggest a low fat / red meat diet and lots of fish and
vegetables.
Exercise - In active phase - rest is important. However once the stiffness starts
to subside - I start to mobilise the patients with hydrotherapy if possible and then
walking progressively more each week.
There are a few
patients who may develop Giant cell arteritis with the development of temporal
distribution headaches - and your doctors should be aware of this potential - as the
therapy for the latter is more aggressive.
However most people do well and the
condition is self limiting in the majority.
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